Titlebook: Cancer Genomics and Proteomics; Methods and Protocol Paul B. Fisher Book 2007 Humana Press 2007 BAC.Carcinom.Chromosom.DNA.Microarray.Trans

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Molecular Cytogenetic Applications in Analysis of the Cancer Genome,ation of complex and cryptic chromosomal changes is beyond the resolution of conventional banding methods. The fluorescence microscopy afforded by imaging technologies, developed recently, facilitates a precise identification of these chromosome alterations in cancer. The three most commonly utilize

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The Use of Phage Display Peptide Libraries for Basic and Translational Research,at proteins. The gene product is encoded by a plasmid contained within the virus, which can be recovered and sequenced, linking the genetic information to the function of the protein. Phage display offers a powerful tool for the identification of short peptides or single chain antibodies that can bi

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Surface-Epitope Masking (SEM),ntibodies (MAbs) reacting with both known and unknown molecules expressed on the cell surface. The tenet underlying SEM involves blocking (masking) of shared antigens between two target populations, a “driver” and a “tester,” and using appropriately modified surface-masked “tester” cells to generate

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Approaches for Monitoring Signal Transduction Changes in Normal and Cancer Cells,ism examined the activities of several highly specific protein and carbohydrate kinases in cell lysates or isolated cell fractions. As more protein kinases were discovered in the 1980s and 1990s, coupled with the development of immunoprecipitating antibodies, in vitro kinase assays of isolated kinas

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PKR in Innate Immunity, Cancer, and Viral Oncolysis,ed immune program. Key components of innate immunity are the interferons (IFNs), a family of related cytokines with potent antimicrobial and immuno-modulatory activities. The IFNs exert their effects through the induction of numerous genes, one of which is the double-stranded RNA-dependent protein k

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Analysis of Transformation and Tumorigenicity Using Mouse Embryonic Fibroblast Cells,ellular senescence that imposes a finite number of divisions in culture. Primary mouse embryonic fibroblast (MEF) cells have a limited growth capacity and on prolonged passaging spontaneously immortalize at a low frequency. In contrast to transformation of primary MEF cells that requires the presenc

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