Titlebook: Calcium-Binding Proteins of the EF-Hand Superfamily; From Basics to Medic Claus W. Heizmann Book 2019 Springer Science+Business Media, LLC,

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Organisationssoziologische Perspektive,uorescent imaging techniques. We initially microinject embryos with the luminescent Ca. reporter, .holo-aequorin, and using a custom-designed luminescent imaging system, we can obtain pan-embryonic visual information continually for up to the first ~24?h postfertilization (hpf). Once we know approxi

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https://doi.org/10.1007/978-3-658-10309-5prevention of disease progression toward major clinical consequences. Molecular imaging technologies play an indispensable role in the clinical field in overcoming these major barriers. The increasing application of imaging techniques and agents in early detection of different diseases such as cance

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Patientenbezogene Dokumentationlure results from poor myocardial relaxation and inadequate filling of the left ventricular chamber caused in part by calcium-handling dysregulation. In this chapter we describe methods to investigate new approaches of novel human Ca. binding protein motifs to restore normal Ca. handling function to

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Brigitte Anderl-Doliwa,Frank Studenskiool for biologists studying calcium signaling for decades. In recent years, CaM has also been implicated in numerous cancer-associated pathways, and rare CaM mutations have been identified as a cause of human cardiac arrhythmias. Here, we present a collection of our most recent and effective protoco

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Frank Studenski,Wolfgang Münsterts. Calcineurin is activated through increased intracellular levels of calcium that is triggered by cell receptors. The phosphatase activity of calcineurin dephosporylates the members of NFAT transcription factor family and activates their translocation to the nucleus and further starts the transcri

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Patientenbezogene Dokumentation reversible binding properties of calpain’s intrinsically disordered protein (IDP) inhibitor, calpastatin. IDPs are easily produced in heterologous expression hosts and purified to homogeneity. Combining these properties with in vivo biotinylation leads to a simplified purification strategy whereby

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Wilhelm Knelangen,Johannes Varwickg proteins. Plastins are involved in the regulation of the actin cytoskeleton as well as the cross-linking of actin filaments. In addition to four calponin-homology (CH) domains, all three plastins contain two N-terminal EF-hand Ca.-binding motifs which together are homologous to a single lobe of th

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https://doi.org/10.1007/978-3-663-10894-8eath, metabolism, and cytoplasmic Ca. signaling. Here we describe the procedures for protein preparation of various MICU2 constructs, which have enabled successful in vitro characterizations of MICU2 including interaction with MICU1 using pull-down assays and oligomerization using multi-angle laser