Titlebook: Bone Metastasis and Molecular Mechanisms; Pathophysiology Gurmit Singh (Director of Research, Professor of P Book 2004 Springer Science+Bus

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Book 2004y of life for patients with breast and prostate cancer. ..Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies. .

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Potential Therapeutic Targets for Bone Metastasis,ast and prostate cancers usually develop bone metastases and tend to harbour the bulk of their tumor burden in their bones at the time of death. The concepts and data reviewed in this chapter relate mainly to these malignancies although some are also relevant to bone metastases secondary to multiple myeloma.

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Springer Series in Materials Scienceoenvironment suited for their proliferation. Circulating cells capable of growing in the bone marrow environment represent the seed. Characteristics of the bone marrow stroma that are conducive for the establishment of a bone metastasis provide the soil.

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Springer Series in Materials Sciencels and the (a)cellular bone marrow stoma lead to differential expression of (lymph)angiogenic factors and their inhibitors in the bone microenvironment, thus explaining -at least in part- the observed bone tropism by a limited number of carcinomas.

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Steven Specter,Gerald Lancz,Ricardo O. Bachfunctions by binding to its receptor RANK on the surface of osteoclasts and their precursors. RANKL is the final mediator of osteoclast activation induced by most, if not all, proresorptive cytokines.

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