Titlebook: Bone Metastasis and Molecular Mechanisms; Pathophysiology Gurmit Singh (Director of Research, Professor of P Book 2004 Springer Science+Bus

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https://doi.org/10.1007/978-3-540-70766-0men and is the second leading cause of cancer mortality following lung cancer (1–3). Recently, increases in the number of men diagnosed with prostate cancer has been attributed to an increase in the awareness of the disease as well as to better improvements in screening and detection. However, despi

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https://doi.org/10.1007/978-3-540-70766-0o spread to bone amongst which are the three most common cancers — lung, breast and prostate. Patients with lung cancer are more likely to succumb quickly to their disease than those with breast or prostate tumors in whom, relatively, bone metastases are more of a problem. Patients with advanced bre

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Steven Specter,Gerald Lancz,Ricardo O. Bach proteins helped to resolve numerous questions regarding the exact molecular mechanisms for bone resorption. These proteins also neatly account for the long-recognized dependence of osteoclasts on the osteoblast/stromal cell population. This pathway was rapidly elucidated after the discovery of oste

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Lithium and Dermatological Disorders,and mortality. They cause clinical disease due to extensive, intractable bone pain, pathological fractures, and spinal cord compression and leads eventually to death. 70% of patients that die of breast cancer have noticeable disease in their bones (1, 2). Similar numbers are found for prostate cance

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https://doi.org/10.1007/978-1-4613-4598-5igure 1). These compounds were first synthesized in Germany in 1865. Their initial use was industrial (textile, fertilizer and oil industries) and for prevention of mineral scaling (due to their ability to inhibit calcium carbonate precipitation). The biological properties of these compounds, howeve

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1568-2102 e cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and pr

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Lithium and Dermatological Disorders,tually to death. 70% of patients that die of breast cancer have noticeable disease in their bones (1, 2). Similar numbers are found for prostate cancer patients (2). Bone disease is also a major problem in multiple myeloma patients. The manifestation of the bone involvement is distinct for the three types of cancers.

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Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer,tually to death. 70% of patients that die of breast cancer have noticeable disease in their bones (1, 2). Similar numbers are found for prostate cancer patients (2). Bone disease is also a major problem in multiple myeloma patients. The manifestation of the bone involvement is distinct for the three types of cancers.