Titlebook: Biological Barriers to Protein Delivery; Kenneth L. Audus,Thomas J. Raub Book 1993 Springer Science+Business Media New York 1993 biochemis

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Transcytosis of Macromolecules through the Blood—Brain Fluid Barriers ,romolecule, transport of that molecule through the cell, and secretion or exocytosis of the molecule from the cell opposite the side of entry. The process has been described for a variety of molecules and a host of cell types; however, no cell type in which transcytosis has been proposed is more con

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Renal Uptake and Disposal of Proteins and Peptidesor the elimination of most small proteins (Maack ., 1985; Rabkin and Kitaji, 1983). In health the glomerular capillary wall almost completely restricts the passage of molecules of molecular radius greater than ~ 42 ? (~ 50 kDa) while increasingly favoring the passage of proteins as their size decrea

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The Immune System as a Barrier to Delivery of Protein Therapeuticser, a protein therapeutic may also be seen as foreign. The result of being perceived as foreign can be benign, neutralize the activity of the therapeutic, or generate an adverse physiological response that may even be lethal. The protein may be intrinsically foreign because it has been obtained from

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978-1-4613-6256-2Springer Science+Business Media New York 1993

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Latency

Carcinoma

Alltagsgestaltung und Erwerbsverhalten,ly active peptides. These ectopeptidases are integral proteins of the plasma membrane, asymmetrically oriented, with the catalytic site exposed at the extracytoplasmic surface (see Fig. 1). For the majority of those ectopeptidases thus far characterized, the protein is anchored in the membrane by a

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