Titlebook: Beta-Lactams; Novel Synthetic Path Bimal K. Banik Book 2017 Springer International Publishing AG 2017 Beta Lactams research.Synthesis antib

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https://doi.org/10.1007/978-3-658-01326-4the synthesis of a variety of mono-, bi- and polycyclic β-lactams since its development in 1996. This novel substrate can be directly alkylated on the nitrogen atom of the β-lactam ring in contrast to commercially available 4-acyloxyazetidin-2-one. Moreover, subsequent cyclization via intramolecular

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https://doi.org/10.1007/978-3-8350-5509-4s chapter will cover significant success in the synthesis of innovative 2-azetidinones through the formation of a single bond, either C–C or N–C. While the C2–C3 bond formation has scarcely been explored, the intramolecular cyclization through the C3–C4 bond using different approaches are among the

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https://doi.org/10.1007/978-3-8350-5509-4s clinically relevant antibiotics, such as penicillins, cephalosporins, carbacephems, monobactam, etc. Therefore, continued efforts are being made in developing new methods for synthesizing β-lactams more efficiently than the previous methods. Solid phase organic (SPS) synthesis of β-lactams has gai

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Spyros Vliamos,Michel S. Zouboulakis in situ formed ketenes, namely amino-, oxy-, thio-, halo- and alkylketenes, are competent reaction partners which upon reaction with the corresponding .-protected C-aryl-, alkyl-, or acyl-imine give access to β-lactam products with a large variety of substitution patterns at the three available pos

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