Titlebook: Aspartic Proteinases; Retroviral and Cellu Michael N. G. James Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusive l

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The Aspartic Proteinasesmewhat primitive technologies. It had a renaissance of biochemical characterisation, followed by a classical period when sequences were defined and catalytic activity identified. It is now very much under the influence of the structural school. Thus, in many ways its history parallels that of painti

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malapropism

A Cellular Anti-Apoptosis Protein is Cleaved by the HIV-1 Proteasetive protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.

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A Comparison of , Precursor Cleavage in Naturally Arising HIV Variantsues to be an important consideration in protease inhibitor therapy. Mutations in protease which lead to resistance have been observed in both inhibitor treated and untreated individuals (Borman et al., 1996; Condra et al., 1995). Variations have also been observed to a higher degree in areas of the