Titlebook: Artificial Nucleases; Marina A. Zenkova Book 2004 Springer-Verlag Berlin Heidelberg 2004 Catalysis.Cleavage.Conjugates.DNA.Enzyme mimics.N

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Book 2004immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme n

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Hemangioma Treatment with Fibrin Sealantms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents.

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Y. Moazami-Goudarzi,C. Khodadadyang elimination of phosphate (and destroying one of the nucleotide units). The purpose of this brief review is to summarise the mechanisms relevant to DNA hydrolysis and in particular to estimate the rate of hydrolysis through attack at the phosphate diester under mild, aqueous conditions.

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Introduction,ms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents.

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Principles of Nucleic Acid Cleavage by Metal Ions,than the properties of nucleic acids due to their smaller size. In fact, both nucleic acids and metal ions exhibit considerable complexity in their interactions, and such interactions could affect the chemical and biochemical properties of both parties.

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Sequence Selective Artificial Ribonucleases Employing Metal Ions As Scissors,pression of a specific gene in cells, advanced therapy, RNA manipulation, and others). However, none of the naturally occurring ribonucleases shows such a high sequence-selectivity. This is why sequence-selective artificial ribonucleases are desirable.