| 期刊全稱 | Aplastic Anemia and Other Bone Marrow Failure Syndromes | | 影響因子2023 | Nasrollah T. Shahidi | | 視頻video | http://file.papertrans.cn/159/158973/158973.mp4 | | 圖書(shū)封面 |  | | 影響因子 | During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup- pressive agents for bone marrow transplantation; failure to achieve en- graftment in some identical twins without prior immunosuppressive ther- apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat- ing the role of activated cytotoxic T lymphocytes and abnormal produc- tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog- nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory i | | Pindex | Book 1990 |
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