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Titlebook: Aplastic Anemia and Other Bone Marrow Failure Syndromes; Nasrollah T. Shahidi Book 1990 Springer-Verlag Inc. 1990 Viruses.anemia.bone marr

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發(fā)表于 2025-3-21 19:01:03 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Aplastic Anemia and Other Bone Marrow Failure Syndromes
影響因子2023Nasrollah T. Shahidi
視頻videohttp://file.papertrans.cn/159/158973/158973.mp4
圖書封面Titlebook: Aplastic Anemia and Other Bone Marrow Failure Syndromes;  Nasrollah T. Shahidi Book 1990 Springer-Verlag Inc. 1990 Viruses.anemia.bone marr
影響因子During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup- pressive agents for bone marrow transplantation; failure to achieve en- graftment in some identical twins without prior immunosuppressive ther- apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat- ing the role of activated cytotoxic T lymphocytes and abnormal produc- tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog- nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory i
Pindex Book 1990
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Die Streumatrix und ihre Symmetrien,to failure of committed progenitor differentiation due perhaps to reduction of steroid-sensitive expression of a specific growth factor receptor gene. Finally, the response of aplastic anemia to antithymocyte globulin or cyclosporine or sometimes prednisone creates the impression that aplastic anemi
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Treatment of Severe Aplastic Anemia: A 12-Year Follow-Up of Patients after Bone Marrow Transplantat of the hip was seen in 4 patients and one developed breast cancer. The most serious late complication after BMT was chronic graft-versus-host disease (GvHD) in patients receiving methotrexate (MTX) for prophylaxis against GvHD.
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Treatment of Severe Aplastic Anemia (SAA) with Bone Marrow Transplantation (BMT) or Immunosuppressits of ALG were superior to BMT for patients not infected (68 vs 60%) or with no hemorrhages at the time of treatment (77 vs 69%). A Cox regression analysis showed that the only significant pretreatment variables were a low neutrophil count (. = 0.001) and increasing age (. = 0.05).
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Bone Marrow Transplantation for Fanconi Anemia,ase (GVHD).. This poor tolerance to alkylating agents has been related to a DNA defect with increased chromosomal instability. Recently, efforts have been made to modify the conditioning regimen according to the cell sensitivity to alkylating agents and to irradiation.
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