Titlebook: Antimicrobial Drug Resistance; Mechanisms of Drug R Douglas L. Mayers Book 2009 Humana Press 2009 Drug.HIV.Handbook.Hepatitis.Malaria.Mayer

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https://doi.org/10.1007/978-1-59745-180-2Drug; HIV; Handbook; Hepatitis; Malaria; Mayers; Resistance; Schistosomiasis; Virus; antibiotics; antimicrobia

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1.2.3 References for 1.2.1 and 1.2.2,The structurally unrelated antimicrobials, macrolides, lincosamides, and streptogramins are grouped into a single family, the MLS family. This classifi cation is justifi ed by a similar, although not identical, mechanism of action.

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Evolutionary Biology of Drug Resistanced by a number of simple phenomena in antibiotic resistance. Variability is created by random mutation, and some of these variants (for instance those with a mutation in the antibiotic target) become resistant. These variants are selected by antibiotic use and consequently they increase the frequency

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Mutations as a Basis of Antimicrobial Resistancee antimicrobial agents are emerging. Bacteria with this phenotype are designated multidrug-resistant (MDR) or pan-drug resistant (PDR) strains. What is the genetic basis of this remarkable survival skill? Are advantageous changes in the genome always random? Is antibiotic pressure the cause of growi

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Target-Mediated Antibacterial Resistancend/or function of the microorganism. In order to do their job effectively, antimicrobial agents must interact with these targets in a manner that precludes the normal functioning of the target molecule. Moreover, their interactions with the target must be fairly specifi c, otherwise the potential fo