Titlebook: Antimicrobial Drug Resistance; Mechanisms of Drug R Douglas L. Mayers Book 2009 Humana Press 2009 Drug.HIV.Handbook.Hepatitis.Malaria.Mayer

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Antibiotic Resistance Due to Reduced Uptake pre-antibiotic era. However, a disturbing trend has also been noted in that, within a very short period of time following the introduction of a new antibiotic, resistance to that antibiotic begins to emerge, a factor that is becoming increasingly meaningful as the discovery of new antibiotics wanes

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Obligatory

The Functional Resistance of Bacterial Biofilmsibiotic therapy, and that an alternative drug must be used. In this chapter, we will concern ourselves with the growing number of bacterial infections in which antibiograms of the causative organism show sensitivity to standard antibiotics in readily attainable concentrations, but the infection fail

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The Importance of β-Lactamases to the Development of New β-Lactamsheir therapeutic use began with the introduction of benzylpenicillin (penicillin G) during World War II (1, 2), and continues with the development of newer cephalosporins and carbapenems for antibioticresistant infections. These agents act by inhibiting bacterial cell wall synthesis, as a result of

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Aminoglycosides: Mechanisms of Action and Resistance They are pseudo-polysaccharides containing amino sugars and can therefore be considered polycationic species for the purpose of understanding their biological interactions. Since they are highly positively charged at physiological pH values, they show high binding affi nity for nucleic acids, espec

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collagen

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Mechanism of Resistance in Metronidazoleaused by various anaerobic and microaerophilic bacteria (Bacteroides, Clostridia, Helicobacter) and parasites (Trichomonas, Giardia, Entamoeba). Other Gram-positive anaerobes (e.g., lactobacilli, propionobacterium acnes, majority of the periodontal pathogens, peptostreptococci) are known to be inher