Titlebook: Antidepressants: Past, Present and Future; Sheldon H. Preskorn,John P. Feighner (President an Book 2004 Springer-Verlag Berlin Heidelberg

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Therapeutic Drug Monitoring of Antidepressants antidepressants). However, the field of psychiatry has been slow to adopt such monitoring as a routine part of care. Research supporting the clinical benefit and cost-effectiveness of TDM with newer antidepressants has also been limited. However, an increasing awareness of how significant inter- an

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Quality of Life and Rating Scales of Depressionssential psychometric properties of depression rating scales is their sensitivity to discriminate between antidepressants and placebo. Among the interview-based rating scales, the Hamilton Depression Rating Scale (HAM-D) is still the one most widely used. It is, however, not a unidimensional scale a

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Overview of Currently Available Antidepressantsical depression, with the only available antidepressants being the tricyclic antidepressants (TCAs), the monoamine oxidase inhibitors (MAOIs), and trazodone. In recent decades, antidepressant drug development has evolved from a process based on chance discovery to a rational development process that

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Tricyclic Antidepressantsbefore they were partly superseded by newer drugs such as the selective serotonin reuptake inhibitors (SSRIs). TCAs were discovered serendipitously, their clinical potential discerned, and their pharmacology was later elucidated. The first members of the class were three-ringed in chemical structure

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Selective Serotonin Reuptake Inhibitorsy prescribed class of antidepressants in the United States and a number of other countries. All the SSRIs except fluvoxamine have an indication for major depressive disorder (MDD) in the United States. The SSRIs were the first rationally developed class of psychiatric medications and thus share many

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