Titlebook: Antibody Phage Display; Methods and Protocol Philippa M. O’Brien,Robert Aitken Book 20021st edition Humana Press 2002

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Rescue of a Broader Range of Antibody Specificities Using an Epitope-Masking Strategy,ries. The strategy uses antigen (Ag)-specific Fabs or single-chain Abs retrieved by an initial selection of the phage libraries to block the corresponding immunodominant epitope. Reselection of the phage library on the masked Ag refocuses the selection against other epitopes on the Ag (..).

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Aerophagia

Karl Küpfmüller,Gerhard Kohn (o. Professor)resentative display libraries from the encoded proteins for screening. In many species, understanding of the basis to Ig formation is now sufficiently detailed for the application of these methods to MAb isolation.

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,Der station?re elektrische Strom,) CA-Hb3, a 50-kDa protein that is recognized by monoclonal antibody (MAb), Hb3 (.), procedures were developed to drive the proliferation of specific B cells from the blood of patients, through exposure to Ag in vitro. This has enabled generation, through phage display, of recombinant human Abs against CA-Hb3.

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https://doi.org/10.1007/978-3-662-25911-5r detection of targets such as environmental pollutants or for monitoring the presence of drugs in clinical samples. There are also applications related to biological functions, e.g., Abs directed against signal molecules enhance the study of cell signaling pathways and have potential as candidate therapeutic agents.

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,Elektromagnetische Ausgleichsvorg?nge,not specific for the target of interest, but which bind to other proteins on the cell surface. Proximity (ProxiMol) selection is a method of selection that enriches the selected population for Abs that bind at or around sites on the cell surface of the target Ag and so reduce the need for labor-intensive screening processes.

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