Titlebook: Anthracycline Chemistry and Biology II; Mode of Action, Clin Karsten Krohn Book 2008 Springer-Verlag Berlin Heidelberg 2008 biochemistry.bi

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Doxorubicin Conjugates for Selective Delivery to Tumors, tumor site while releasing the cytotoxic drug..Among immuno-conjugates representing a?widely studied class of doxorubicin derivatives,the clinical development of cBR96-Dox, undoubtedly the most quintessential derivative, was discontinueddue to severe secondary effects. More potent cBR-96 analogues

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,Anthracycline–Formaldehyde Conjugates and Their Targeted Prodrugs,raquinones, and as such are redox active. Their redoxchemistry leads to induction of oxidative stress and drug metabolites. An intermediate in reductive glycosidiccleavage is a?quinone methide, once proposed as an alkylating agent of DNA. Subsequent research nowimplicates formaldehyde as a?mediator

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Nemorubicin,armitalia CarloErba Research Center in Italy. The idea was to develop doxorubicin analogues able to circumvent the emergenceof chemoresistance, in particular the multi-drug resistance. The drug was reported to be active in vitroagainst both murine and human tumor cells resistant to doxorubicin. Simi

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Anthracycline Chemistry and Biology II978-3-540-75813-6Series ISSN 0340-1022 Series E-ISSN 1436-5049

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Karsten KrohnSeries presents critical reviews of the present position and future trends in modern chemical research.Short and concise reports on chemistry, each written by the world renowned experts. Still valid a

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978-3-642-09495-8Springer-Verlag Berlin Heidelberg 2008