Titlebook: Anthracycline Chemistry and Biology II; Mode of Action, Clin Karsten Krohn Book 2008 Springer-Verlag Berlin Heidelberg 2008 biochemistry.bi

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https://doi.org/10.1007/978-3-322-94758-1d via P450 CYP3A enzyme to an extremely cytotoxicderivative. Both nemorubicin and its metabolite have a?mechanism of action different from that ofdoxorubicin, with a?key role played by the nucleotide excision repair system. The drug is activelytested in clinics as a?single agent or in combination with cisplatin.

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Nemorubicin,d via P450 CYP3A enzyme to an extremely cytotoxicderivative. Both nemorubicin and its metabolite have a?mechanism of action different from that ofdoxorubicin, with a?key role played by the nucleotide excision repair system. The drug is activelytested in clinics as a?single agent or in combination with cisplatin.

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Acid-Sensitive Prodrugs of Doxorubicin,for designing carrier-linked prodrugs with pH-dependentlinkers. In the past 20 years, a?spectrum of acid-sensitive doxorubicin prodrugs has been developedwith antibodies, serum proteins, and synthetic polymers. For a?number of these, a?convincingproof of concept has been obtained preclinically, show