Titlebook: Alzheimer’s Disease Research; What Has Guided Rese Christian Behl Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusiv

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The , Has to Deliver, Finally, increasing and the disease been acknowledged as a major health problem. More than 2000 clinical trials targeting different mechanisms were performed, and no breakthrough therapy showing convincing clinical benefit in patients could be found so far. Numerous hypotheses were formulated in the attempt

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Beyond ,, ,, ,, and ,: What Else Does the Genome Tell Us?,up of genetic familial disease cases, and they are dominantly inherited (full penetrance; early-onset autosomal-dominant Alzheimer’s disease). Independently of these “Alzheimer genes”, in 1993, the gene coding for the apolipoprotein E (APOE) was presented as an Alzheimer’s risk gene with high penetr

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Is the Persistence of the , a Result of Constant Confirmation Bias?,of researchers who?challenge it. The current “defect” of the . is that its supporters see their ultimate proof in the clinical success of clearing amyloid beta from the brain of affected individuals. However, so far, removal of the peptide did not result in a convincing clinical benefit or breakthro

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Book 2023s still not been convincingly proven in the clinics? Are there other hypotheses that might explainthe pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed?.In this book, Behl tries to answer these questions. Starting with the historical backgroun