Titlebook: Alzheimer’s Disease Research; What Has Guided Rese Christian Behl Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusiv

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,Alzheimer’s Disease Research After 1945: The Recommencement,ative disorders. In addition to Alzheimer’s, several other types of dementia exist. Alzheimer’s disease?research officially set off with the introduction of the label “Alzheimer’s disease” in 1910, but similar neurodegenerative processes had already been described years before..The restart of Alzhei

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,The , of Alzheimer’s Disease,itatory neurotransmitter in the vertebrate nervous system. This neurotransmitter displays its activities via different types of receptors localized at the nerve cell membrane. Physiologically, glutamate and its receptors (especially the so-called NMDA type) are involved in higher brain functions suc

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,Biochemistry and Genetics Point Out a Prime Suspect for Causing Alzheimer’s Disease,rsh chemical conditions, the sequence of 24 amino acids of the amyloid beta peptide isolated from cerebrovascular material was unraveled at the UCSD by Georg Glenner and Caine Wong in 1984. Shortly thereafter, the German and Australian researchers Konrad Beyreuther and Colin Masters, respectively, p

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Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor, peptide. A fierce competition commenced?between several research groups during the year 1987 around the further molecular characterization of this peptide..Key findings were the cloning of its precursor protein (APP), the molecular assignment of the APP gene to chromosome 21, and the discovery that

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,Step by Step Toward an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease,of molecular and cellular findings around this peptide was delivered and, consequently, in 1992 the . was presented. This hypothesis assigned the amyloid beta protein the role as initial trigger standing at the beginning of a cascade of pathogenic events. In the 15?years from 1984 to 1999, the puzzl

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