Titlebook: Alzheimer’s Disease; Methods and Protocol Jerold Chun Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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書目名稱Alzheimer’s Disease影響因子(影響力)




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FISHing for Chromosome Instability and Aneuploidy in the Alzheimer’s Disease Braining the brain. Although the types and rates of chromosome instability in the AD brain remain a matter of debate, molecular cytogenetic analysis of brain cells appears to be important for uncovering mechanisms of neurodegeneration. Here, we describe a FISH protocol for studying chromosome instability and aneuploidy in the AD brain.

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Edgar R??ger,Klaus Haucke,Erbard Jadend vasculature, enables sensitive detection of focal BBB vascular abnormalities, and reveals the spatial distribution of Aβ plaques and fibrin deposits, in large tissue volumes from cleared human brains. Overall, fibrinogen iDISCO enables the investigation of neurovascular and neuroimmune mechanisms driving neurodegeneration in disease.

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Extraction and Purification of Single Nuclei from Frozen Human Brain Tissuecells, processes, and synapses—which precludes intact and selective isolation of single brain cells. Here, we describe a protocol for the extraction and purification of intact single nuclei from frozen human brain tissue along with modifications to accommodate numerous downstream analyses, particularly for transcriptomic applications.

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Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electar membranes in human postmortem brain samples, as well as the steps necessary to acquire scanning electron microscopy (SEM) images of microglial cell bodies. In the last section, we cover the quantitative analysis of various microglial cytoplasmic organelles and their interactions with other parenchymal elements.

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Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer’s Diseased vasculature, enables sensitive detection of focal BBB vascular abnormalities, and reveals the spatial distribution of Aβ plaques and fibrin deposits, in large tissue volumes from cleared human brains. Overall, fibrinogen iDISCO enables the investigation of neurovascular and neuroimmune mechanisms driving neurodegeneration in disease.