Titlebook: Glycoimmunology 2; John S. Axford Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+B

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savage

The Structure of a Human Rheumatoid Factor Bound to IgG Fc patients with rheumatoid arthritis (RA), and high levels of RF are associated with severe disease and poor prognosis (2,3) suggesting that they have a causative role in the pathology of this disease. The IgM or IgG RFs form immune complexes with IgG molecules in the joints, which can then activate

間接

Carbohydrate Recognition Systems in Innate Immunityal situation of receptor-ligand pairs., a picture is emerging of recognition systems that operate as triads: receptors, ligands and carriers. Here the receptors are lectins., the ligands are oligosaccharides, and when they are optimally assembled on carriers (proteins or lipids) functional counter-r

淺灘

關(guān)節(jié)炎

Endothelial Sialyl Lewis X as a Crucial Glycan Decoration on L-Selectin Ligandshocytes is initiated by the interaction of members of the selectin family and their ligands, which leads to a vascular shear flow-dependent rolling on the endothelial surfaces.. Of the three identified selectins, L-selectin is expressed on leukocyte surfaces and it recognizes glycoprotein ligands on

CAND

Role of Lectin-Glycoconjugate Recognitions in Cell-Cell Interactions Leading to Tissue Invasiongnificance was shown in developmentally regulated processes of cell migration, embryonic maturation, differentiation and during various other normal and pathological processes..This work will focus on the role of endogenous lectins and their glycoconjugate ligands in homing of circulating normal and

paroxysm

Protein O-GlcNAcylation: Potential Mechanisms for the Regulation of Protein Functionerine and threonine residues. O-GlcNAc was originally identified while probing the surfaces of lymphocytes using UDP-[.H] galactose and highly purified galactosyltransferase (1). O-GlcNAc was not a substrate for galactosyltransferase unless the cell membrane was first disrupted with detergents indic

Albumin

A Longitudinal Study of Glycosylation of a Human IgG3 Paraprotein in a Patient with Multiple Myelomale accounts for only 23% of its mass it has been shown to be essential for optimal activation of effector mechanisms leading to the clearance and destruction of pathogens., ., .. Human antibody molecules of the IgG class have N-linked oligosaccharide attached at the amide side chain of Asn-297 in th

Abrade

The Role of the Lectin Calnexin in Conformation Independent Binding to N-Linked Glycoproteins and Qu experimental support has now been put forward as a consequence of studies with the endoplasmic reticulum resident membrane protein calnexin and its luminal homologue calreticulin. These resident proteins, at least one of which (calnexin) is universal to all eukaryotes, act principally as lectins wh

類似思想

Immunodetection of Glycosyltransferases: Prospects and Pitfallsates are the enzymes involved in their construction: the glycosyltransferases. Their investigation relies on three basic pillars: i) the biochemical which comprises methods for their purification and assays for enzymic activity; ii) the cell biological which is usually based on antibodies providing