Titlebook: Advances in Research on Neurodegeneration; P. Riederer,D. B. Calne,M. B. H. Youdim Conference proceedings 2000 Springer-Verlag Wien 2000 A

Bridle

放肆的我

,Importance of familial Parkinson’s disease and parkinsonism to the understanding of nigral degeneraenesis of PD is supported by the demonstration of the high concordance in twins, increased risk among relatives of PD patients in case control and family studies, and the existence of familial PD and parkinsonism based on single gene defects. Recently, several genes have been mapped and/or identifie

種屬關(guān)系

cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in Mal dopamine neurodegeneration and its protection with R-apomorphine. Both MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and R-apomorphine (R-APO) induced alterations in specific patterns of gene expression. MPTP altered the expression of 49 different genes involved in oxidative stress (oxidati

聯(lián)合

,Monitoring neuroprotection and restorative therapies in Parkinson’s disease with PET,ussed. The potential value of PET and SPECT for assessing the efficacy of putative neuroprotective agents in PD is considered and a review of 18F-dopa PET findings in transplantation trials involving implantation of human and procine fetal mesencephalic tissue is presented. It is concluded that func

ANIM

媽媽不開(kāi)心

TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activitieMAO)-B inhibitor, rasagiline (N-propargyl-(1R)aminoindan), possessing both cholinesterase (ChE) and MAO-inhibitory activity. In doses of 35-100 μmoles/kg administered orally to rats, it inhibits ChE by 25-40% and antagonises scopolamine-induced impairments in spatial memory. After daily administrati

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匍匐前進(jìn)

Neurorescuing effects of the GAPDH ligand CGP 3466B,ng properties. It is metabolized to (-)-desmethyldeprenyl, which seems to be the active principle, and further to (-)-amphetamine and (-)-methamphetamine, which antagonize its rescuing effects. These complications may explain the limited neurorescuing potential of (-)-deprenyl observed clinically.

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