Titlebook: DNA-Encoded Chemical Libraries; Methods and Protocol David Israel,Yun Ding Book 2022 Springer Science+Business Media, LLC, part of Springer

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Initiating DNA-Encoded Library Synthesis with a Hexathymidine DNA Oligonucleotide,starts with a solid phase-bound, chemically very stable hexathymidine DNA sequence “hexT.” Different heterocycle conjugates of the hexT oligonucleotide were synthesized from simple starting materials using metal or acid catalysts. The hexT conjugates were isolated, characterized, and ligated to coding DNA sequences.

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DNA-Encoded Chemical Libraries978-1-0716-2545-3Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Lecture Notes in Computer Sciencensuring the quality of a library. Here we describe the validation method used to assess the reactivity of potential building blocks to be included in a DNA-encoded library, with HATU acylation of carboxylic acid building blocks with an on-DNA amine substrate as an example.

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只看該作者 · 發(fā)表于 2025-3-30 07:18:04

Chemical Ligation of Oligonucleotide Tags to Support Encoded Chemical Library Synthesis,pargyl and 5′-azido oligonucleotides. We also present methods for the synthesis of phosphorothioate junctions from 3′-thiophospho and 5′-iodo oligonucleotides and for the synthesis of phosphodiester junctions from both 3′-hydroxy and 5′-phospho- and 3′-phospho and 5′-hydroxy oligonucleotides using 1-cyanoimidazole.

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