Titlebook: DNA-Encoded Chemical Libraries; Methods and Protocol David Israel,Yun Ding Book 2022 Springer Science+Business Media, LLC, part of Springer

MEAN

Metamorphosis

Target Protein Design and Preselection Analysis,ures compared to other small molecule screening technologies, such as the use of DNA identification tags and use of target protein immobilization in the standard library screening process. Therefore, it is of great importance to ensure the target protein is properly designed for DEL selections, that

儀式

DEL Selections Against a Soluble Protein Target,process that involves incubation of a target protein with the DEL, capture of the protein and associated DEL compounds on a solid support, separation of bound molecules from the bulk DEL that is unbound, and recovery of bound DEL molecules. Each step is of great importance in order to achieve succes

Onerous

Adaptive Learning Goes to Chinacts the quality of the hits arising out of a selection assay, while proper sample handling and tracking ensure follow-up synthetic work is done with the appropriate synthetic map in mind. In this chapter, possible strategies for building block selection are outlined, as well as best practices for ha

Triglyceride

Functional

殘廢的火焰

accrete

Tianchong Wang,Eric C. K. Chenginteresting target; several small molecular inhibitors have moved into the late-stage clinical development. The success of DEL is heavily dependent on the chemical space which was assembled by the on-DNA chemical reactions. On-DNA C-N cross-coupling has great value for expanding the chemical space o

運(yùn)氣

Silent-Ischemia