Titlebook: Voltage-Gated Calcium Channels; Gerald Werner Zamponi,Norbert Weiss Book 2022 The Editor(s) (if applicable) and The Author(s), under exclu

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Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengerssiological responses through the control of intracellular calcium. They mediate the depolarization of cells and increase the intracellular Ca. levels to regulate a variety of physiological events including neurotransmission, secretion, enzyme activity, cellular differentiation, gene expression, smoo

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Calmodulin Regulation of Voltage-Gated Calcium Channelsl of Ca. entry into cardiomyocytes and neurons. Over the past three decades, this modulation has emerged as a prototype for ion channel regulation with important physiological and pathophysiological implications. In this chapter, we summarize key findings pertaining to structural and biological mech

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Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Micepes and to understand their physiological significance, sensitivity to pharmacological agents has been the most prevailing criterion. However, not all the types enjoyed the merit of pharmacology, as we didn’t have selective high-affinity blockers for T-, Q-, and certain L-types, when they were first