Titlebook: Voltage-Gated Calcium Channels; Gerald W. Zamponi Book 2005 Springer-Verlag US 2005 Activation.Biophysics.Peptide.cardiovascular.distribut

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The Calcium Channel and the Transmitter Release Site,Ca. ions that leads to the activation of the transmitter release mechanism, a feed-forward pathway, but it is in itself modulated by a complex web of molecular interactions that involve both transmitter release site and non-release site proteins. Clearly, we do not yet nearly understand the full com

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Ca2+-Dependent Modulation of Voltage-Gated Ca2+ Channels,flux through these channels. Ca.1.2 (L-type) and Ca.2.1 (P/Q-type) channels undergo a dual feedback regulation by Ca., which is manifested as enhanced facilitation and inactivation of Ca. currents compared to Ba. currents. Ca.-dependent facilitation and inactivation are distinct biophysical processe

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Voltage-Dependent Inactivation of Voltage Gated Calcium Channels, of calcium entering excitable cells during membrane depolarizations. The association with ancillary β subunits regulates the inactivation characteristics of the α. subunit through functional (and possibly direct) interactions between the β subunit and N-terminal region of the α. subunit. Moreover,

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Selective Permeability of Voltage-Gated Calcium Channels,he emerging description differs from that for potassium channels, which make use of a stiff filter lined with main chain carbonyl oxygens that snugly fit K. ions. Instead, calcium channels use a selectivity filter composed of the side chain carboxylate oxygen atoms of a cluster of four glutamate res

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Block of Voltage-Gated Calcium Channels by Peptide Toxins,ium channels in normal and pathological conditions. Several members of the ω-conotoxin class of calcium channel blockers are currently in clinical trials for chronic pain. While they are particularly efficacious when delivered intrathecally, side effects may limit their usage. Future advances will c

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Book 2005ulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar- macological targets in the treatment of a variety of disorders, such as epi- lepsy, hypertension, and pain. Voltage-gated calcium channels have there- fore been subje

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Christina I. Schroeder,Richard J. Lewis,David J. Adamsamined to reveal the effects of each step of the pairing process. Several photos, videos, thumbnails and metadata files originating from Spectacles devices were obtained and tied to specific times, devices and locations. The research provides interesting insights into evidence collection from Spectacles devices paired with Apple iPhones.

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