Titlebook: Vogel and Motulsky‘s Human Genetics; Problems and Approac Michael R. Speicher,Arno G. Motulsky (Professor Em Book 2010Latest edition Spring

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History of Human Genetics*,Greek literature. In the eighteenth and nineteenth centuries observations were published on the inheritance of numerous diseases, including empirical rules on modes of inheritance. The history of human genetics as a theory-based science began in 1865, when Mendel published his Experiments on Plant H

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Formal Genetics of Humans: Modes of Inheritance*,ocus lead to genetically identical offspring (F. generation), heterozygous for this allele. It is unimportant which of the two homozygotes is male and which is female (law of uniformity and reciprocity). Such reciprocity applies only for genes not located on sex chromosomes..2. When these F. heteroz

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Linkage Analysis for Monogenic Traits, and locating genes that cause disease, or genetic traits. Although these methods have been partially supplanted by newer methods such as whole genome sequencing, linkage analysis still has considerable utility. The history of the method and the mathematical basis of linkage analysis are presented a

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Oligogenic Disease,ssist in the diagnosis and management of disease. Recent work, originating primarily from disorders thought to be traditionally inherited in a Mendelian fashion, have blurred the boundaries between allele causality in monogenic and complex disease. Studies on genetic variation in disease are now rev

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Formal Genetics of Humans: Multifactorial Inheritance and Common Diseases,th many environmental factors. In this chapter the historical concepts of quantitative genetics, including additive variance and heritability, will be developed to underscore how important it is to understand that the root of the problem is to explain how genes contribute to the variance in a trait.