Titlebook: Vitamin D in Chronic Kidney Disease; Pablo A. Ure?a Torres,Mario‘Cozzolino,Marc G.‘Verv Book 2016 Springer International Publishing Switze

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Epidemiology of Vitamin D Deficiency in Chronic Kidney Diseaseevel. While some studies report significant, positive, and independents associations between glomerular filtration rate and circulating 25(OH)D values, others show low levels only in advanced CKD stages. Still others show no or even an inverse association, with paradoxically higher levels of 25(OH)D

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Molecular Biology of Vitamin D: Genomic and Nongenomic Actions of Vitamin D in Chronic Kidney Disease survival, and (c) Synergistic VDR activation by calcitriol and its precursor, 25-hydroxyvitamin D, to counteract VDR reductions..Special focus is directed to the molecular bases supporting the paradigm switch to maximize calcitriol/VDR anti-aging actions. Specifically, from suppression of the PTH

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Vitamin D and FGF23 in Chronic Kidney Diseasetriol directly stimulates FGF23 production in osteocytes. The physiological action of FGF23 requires the expression at the cell surface of a FGFR and the co-receptor αklotho. αKlotho is mainly expressed in the kidney, brain, and in the muscle. Calcitriol stimulates αklotho expression. αKlotho can be

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