Titlebook: Visceral Pain; Stuart M. Brierley,Nick J. Spencer Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irriing relayed to the central nervous system (CNS). Vagal and spinal afferents are likely to act as the primary interrogators of peripheral intestinal signals, and activation of intestinal nociceptors is associated with the central interpretation of visceral pain. For most of us, gut-to-brain communica

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A Fentanyl Analogue That Activates u-Opioid Receptors in Acidified Tissues Inhibits Colitis Pain wispiratory depression and sedation. The development of a fentanyl analogue, (±)-.-(3-fluoro-1-phenethylpiperidine-4-yl)-.-phenyl propionamide (NFEPP), which preferentially activates μ opioid receptors (MOPr) in acidified microenvironments of diseased tissues, represents a novel alternative for inhibi

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Translating Colonic Sensory Afferent Peripheral Mechanosensitivity into the Spinal Cord Dorsal Horn what manner incoming sensory input is conveyed into the brain. The spinal cord is therefore a key relay point shaping how colonic nociceptive stimuli are ultimately perceived. This minireview summarises what is currently known of the spinal cord circuits that receive sensory input from the colon an

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Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensiripheral and central sites of the sensory afferent pathways that relay nociceptive signals into the brain. Sensitisation within the spinal cord is an important mechanism maintaining chronic visceral pain beyond colitis resolution and facilitates the development of cross-organ sensitization. This min

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Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain,ome (IBS). The pathological mechanisms of chronic visceral pain have not been fully resolved. Pain management remains challenging and a source of frustration for health-care providers as current treatments are limited and lead to many side effects. Growing evidence indicates that functional changes

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Pre-clinical Models of Endometriosis: A Focus on Chronic Pain, with endometriosis, leaving patients frequently suffering from widespread pain, often associated with painful comorbidities. Despite this significant disease burden, limited progress has been made in elucidating the mechanisms contributing to endometriosis-associated CPP development. Accordingly, t

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