Titlebook: Viral Proteases and Antiviral Protease Inhibitor Therapy; Proteases in Biology Uwe Lendeckel,Nigel M. Hooper Book 2009 Springer Science+Bus

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Picornaviruses,bility of potent antiviral compounds would be an appreciable advantage in fighting these pathogens. Inside their non-enveloped capsid, picornaviruses possess a positive sense RNA genome with a single open reading frame. Upon release into the cytoplasm, the genome is translated into a single polyprot

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HIV-1 Protease and AIDS Therapy,inding to resistant mutants of HIV protease, and provide high genetic barriers to resistance. Recent developments are described in these structure-guided designs for antiviral therapy based on targeting the HIV-1 protease and its drug resistant mutants.

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Hepatitis C Virus,ng of the biochemistry and structural biology of NS2/3 and NS3 cleavage. We also discuss their roles in the viral life cycle, and highlight the current and future development of antiviral therapy targeted to these protease activities.

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Antiviral Activity of Proteasome Inhibitors/Cytomegalovirus, different mode of action. In this chapter we will review the impact of proteasome inhibition on HCMV replication and discuss whether the use of proteasome inhibitors is a possible strategy to prevent viral replication.

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