Titlebook: Vascular Adhesion Molecules and Inflammation; Jeremy D. Pearson Book 1999 Birkh?user Verlag 1999 biology.cell.cell biology.diseases.inflam

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Adhesion of leukocytes from flow: The selectins and their ligands,ls range from 1 to 10 mm/s, allowing for blood transit times on the order of 0.1 to 0.01 s for a 100 μm segment of venule. This time interval is too short to ensure activation and attachment of leukocytes suspended in the flowing blood.

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The role of PECAM in leukocyte emigration,our ability to block the actions of these molecules by specific monoclonal antibodies (mAb), soluble recombinant CAMs or their ligands, or genetic disruption that has identified these as distinct steps [1,2].

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Co-operative signaling between leukocytes and endothelium mediating firm attachment,ll possible signaling steps in the cascade of events leading to stable adhesion (though signaling pathways will not be discussed). In addition, simple observations of cell interactions will be presented to emphasize the potential influence of surface topography on the sequence of events that control firm adhesion and its localization.

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Quantification and imaging of vascular adhesion molecule expression in inflammatory diseases ,,vide possible targets [3]. Molecular probes to these might be clinically useful for imaging inflammation and provide more readily interpretable information than that supplied by existing techniques [4]. In this chapter we describe our experience evaluating E-selectin and vascular cell adhesion molecule-1 (VCAM-1) for this purpose.

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Book 1999trafficking and also critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The book is designed to provide up-to-date, linked reviews of the subject suitable for postgraduate students entering the field or research workers from allied disciplines needing a modern overview.

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How early studies of inflammation led to our current views on the roles of vascular adhesion molecubar to detect sites of leakage. The resulting drawings (e.g. Fig. 1) accurately demonstrate the early stages of the acute inflammatory process in as much detail as many contemporary textbooks. He was also perspicacious enough to attribute emigration to a molecular process, writing: “.”.

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Oxidation-reduction sensitive regulation of vascular inflammatory gene expression,play a role in signal transduction processes such as cell growth and posttranslational modification of proteins. It is now apparent that oxidants, antioxidants and other determinants of the intracellular reduction-oxidation (redox) state play an important role in the regulation of gene expression [1, 2].