Titlebook: V(D)J Recombination; Pierre Ferrier Book 2009 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science

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Regulation of V(D)J Recombination by E-Protein Transcription Factors,ulating V(D)J recombination in both B- and T-cells. The study of E-proteins in mammals began with the identification of E2A by its ability to bind immunoglobulin heavy and light chain enhancers. Subsequent analysis has identified numerous roles for E2A and HEB at the immunoglobulin and T-cell recept

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Temporal and Spatial Regulation of V(D)J Recombination: Interactions of Extrinsic Factors with the ately responsible for several features peculiar to lymphoid development, including the lineage specificity of antigen receptor assembly, allelic exclusion and receptor editing. In addition, cell cycle phase-dependent regulation of V(D)J recombinase activity ensures that DNA rearrangement is complete

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V(D)J Recombination: Of Mice and Sharks,ymphocytes and T-cell receptors (TCR) in T-lymphocytes. The Ig and TCR diversity is generated by a process called V(D)J recombination, which is initiated by the RAG recombinase. Although RAG activity is very well conserved, the regulated accessibility of the antigen receptor genes to RAG has evolved

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Book 2009nique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way o

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re their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen

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Evelyne Jouvin-Marche,Patrizia Fuschiotti,Patrice No?l Marcheen Sammlungen und Institute ihren Platz; der das Geb?ude umziehende, damals auf allen vier Seiten durch einen Weiher gegen die Strasse hin abgegrenzte Schlossgarten fand als botanischer Garten geeignetste Verwendung.

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