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Titlebook: Unclassifiable Leukemias; Proceedings of a Sym Marcel Bessis,George Brecher Conference proceedings 1975 Springer-Verlag Berlin Heildelberg

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書目名稱Unclassifiable Leukemias
副標題Proceedings of a Sym
編輯Marcel Bessis,George Brecher
視頻videohttp://file.papertrans.cn/942/941165/941165.mp4
圖書封面Titlebook: Unclassifiable Leukemias; Proceedings of a Sym Marcel Bessis,George Brecher Conference proceedings 1975 Springer-Verlag Berlin Heildelberg
描述Jean BERNARD * I should like to begin with an assumption and a paradox. The assumption is that leukemia is a disease of a stem cell characterized by pathologie alterations of that cell and its progeny. All present research and discussions are centered around the leukemic cell. So is this symposium, which would not take place except for our primary interest in the leukemic cell. This does not preclude, of course, consideration of other definitions and other approaches to the prOblem. By definition, then, the leukemic cells are abnormal cells and their metabolism and functions are presumed to be abnormal. Yet, the classification of the different types of leukemias is based upon the characteristics of normal cells. We talk of "lymphoblasts" and "myeloblasts" as predominant cell types in leukemia. This leads to a double paradox. In the first pi ace it is clearly illogical to classify abnormal cells by their resemblance to normal cells, since their very abnormality consists in not being normal. Yet, as a second paradox, the classifica- ti on has had the happy consequence of ai ding us in the treatment and prognosis of leukemia for the past 25 years. A more detailed analysis shows that t
出版日期Conference proceedings 1975
關鍵詞Leukemias; anemia; blood; cell; chemistry; classification; diagnosis; leukemia; metabolism; pathology; physiol
版次1
doihttps://doi.org/10.1007/978-3-642-66126-6
isbn_softcover978-3-540-07242-3
isbn_ebook978-3-642-66126-6
copyrightSpringer-Verlag Berlin Heildelberg 1975
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DiscussionIn answer to . question as to whether . method would give correct results if some cells were elliptical: the method presumes spherical shape of the cells, and a different program would be needed for elliptical cells.
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Fluorescence Probe and Biochemical Characterization of Leukaemic Cellsudies indicate that the reaction patterns emerging as a response to mitogens, manifesting in changes in the cytoplasm structuredness, combined with molecular biological studies of the turnover state and character of macromolecular RNA fractions, could be useful for the characterisation of leukaemias.
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G. Flandrin,Jean Bernardor gene targeting and genome editing, as well as the current state of next generation sequencing. With more than 140 illustrations, this new edition provides an invaluable text for students and anyone who have interest in gaining proficiency in reading and speaking the language of gene cloning..
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