| 書目名稱 | Tumor Suppressor Par-4 | | 副標(biāo)題 | Role in Cancer and O | | 編輯 | Vivek M. Rangnekar | | 視頻video | http://file.papertrans.cn/931/930830/930830.mp4 | | 概述 | Provides researchers and clinicians with new insights into potential drug discovery and development for various cancers and other human diseases.Describes the role of Par-4 in diverse diseases and the | | 圖書封面 |  | | 描述 | Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials...This second, companion volume will provide a comprehensiv | | 出版日期 | Book 2021 | | 關(guān)鍵詞 | lung cancer; ovarian cancer; nasopharyngeal carcinoma; GI tumors; endometrial cancer; prostate cancer; pan | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-80558-6 | | isbn_ebook | 978-3-030-80558-6 | | copyright | Springer Nature Switzerland AG 2021 |
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