| 書目名稱 | Tumor Biomarker Discovery | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Michael A. Tainsky | | 視頻video | http://file.papertrans.cn/931/930778/930778.mp4 | | 概述 | Provides a detailed overview of the range of biomarker technologies as written by leading researchers in the field.Useful both for researchers interested in new tumor biomarkers and physicians seeking | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | Biomarkers are molecular indicators of a biological status and, as biochemical species, can be interrogated to evaluate disease status and therapeutic interventions. Biomarkers may be detectable in the blood, other body fluids, or tissues. The expectation is that the level of an informative biomarker is related to the specific type of disease present in the body. Hence, disease-relevant biomarkers can be used to measure the presence, progress, or intensity of disease. Through a variety of mechanisms, cancer cells provide the biomarker material for their own detection. Tumor biomarkers include cancer-specific mutations or changes in gene expression, both of which can result in aberrant protein expression. These variant or abundant proteins can be detectable in the circulation as the free proteins or as novel autoantibodies to those proteins, the latter indicating that the immune system can provide an exquisitely sensitive sensor of disease. Because cancer cells shed DNA in the circu- tion, an event rarely seen in healthy individuals, tumor-specific genetic changes, such as promoter methylation or gene mutations, are detectable in DNA prepared from plasma or other body fluids. Cancer | | 出版日期 | Book 2009 | | 關(guān)鍵詞 | 2D liquid chromatography; Antigen; Biomarker analyte panels; Cancer detection; Human immune system; Labor | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60327-811-9 | | isbn_softcover | 978-1-61737-915-4 | | isbn_ebook | 978-1-60327-811-9Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2009 |
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