| 書目名稱 | Transforming Growth Factor-Beta in Cancer Therapy, Volume II | | 副標(biāo)題 | Cancer Treatment and | | 編輯 | Sonia B. Jakowlew | | 視頻video | http://file.papertrans.cn/929/928478/928478.mp4 | | 概述 | Details the role of TGF- ? in cancer treatment and therapy, including its role in development and progression of several different cancers.Conveniently divided into three easy-to-follow parts.Companio | | 叢書名稱 | Cancer Drug Discovery and Development | | 圖書封面 |  | | 描述 | Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood. | | 出版日期 | Book 2008 | | 關(guān)鍵詞 | Activation; DNA; Endoplasmatisches Reticulum; Vivo; angiogenesis; carcinoma; gene transfer; genes; leukocyte | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-293-9 | | isbn_softcover | 978-1-61737-736-5 | | isbn_ebook | 978-1-59745-293-9Series ISSN 2196-9906 Series E-ISSN 2196-9914 | | issn_series | 2196-9906 | | copyright | Humana Press 2008 |
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