| 書目名稱 | Toxicology of Metals | | 副標(biāo)題 | Biochemical Aspects | | 編輯 | Robert A. Goyer (Professor Emeritus),M. George Che | | 視頻video | http://file.papertrans.cn/928/927271/927271.mp4 | | 叢書名稱 | Handbook of Experimental Pharmacology | | 圖書封面 |  | | 描述 | The toxicology of metals has been concerned in the past with effects that produced clinical signs and symptoms. However, this view of metal toxicology has expanded in recent years due principally to two advances. There has been a considerable increase in our knowledge of the biochemical effects of metals. In addition, biomarkers of toxicity can now be recognized that identify toxicity at levels of exposure that do not produce overt clinical effects. Thus, the toxicology of metals is now focused on nonclinical events that reflect adverse health effects. This new awareness has produced the challenge of determining the lowest adverse level of exposure. With increasing analytical sensitivity and methodologies to detect small changes at the molecular level, the lowest level of exposure of some toxic metals, like lead, is very small. Indeed, for metals in which there is no biologic requirement, it may be questioned whether there is a level of exposure that does not produce some degree of toxicity. For essential metals, the question is being asked as to the levels at which exposure exceeds biologic require- ments and excess exposure becomes toxic. The appropriateness of health decisions a | | 出版日期 | Book 1995 | | 關(guān)鍵詞 | Chelate; Metal Chelation; Metalle; Toxic Metals; Toxikologie; chromium; gene expression; health effects; hum | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-79162-8 | | isbn_softcover | 978-3-642-79164-2 | | isbn_ebook | 978-3-642-79162-8Series ISSN 0171-2004 Series E-ISSN 1865-0325 | | issn_series | 0171-2004 | | copyright | Springer-Verlag Berlin Heidelberg 1995 |
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