| 書目名稱 | The Unfolded Protein Response in Cancer | | 編輯 | Robert Clarke | | 視頻video | http://file.papertrans.cn/922/921665/921665.mp4 | | 概述 | Explores the unfolded protein response, including its activation and repression, its effect on cancer cell biology, and its potential as a novel target for drug development.Provides an overview of cut | | 叢書名稱 | Cancer Drug Discovery and Development | | 圖書封面 |  | | 描述 | .This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation.. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.. | | 出版日期 | Book 2019 | | 關鍵詞 | Cells; Hypoxia; PERK; Resistance; Unfolded protein response | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-05067-2 | | isbn_ebook | 978-3-030-05067-2Series ISSN 2196-9906 Series E-ISSN 2196-9914 | | issn_series | 2196-9906 | | copyright | Springer Nature Switzerland AG 2019 |
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