| 書目名稱 | The Sliding-Filament Theory of Muscle Contraction | | 編輯 | David‘Aitchison Smith | | 視頻video | http://file.papertrans.cn/920/919806/919806.mp4 | | 概述 | This book is the first to provide a unified description of the mathematics of muscle contraction.It provides a synthesis of theory and experiment in a field which has been driven to maturity by experi | | 圖書封面 |  | | 描述 | .Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. .After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, ho | | 出版日期 | Book 2018 | | 關(guān)鍵詞 | Muscle; Contractions; Motility; Regulation; Sliding filaments | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-03526-6 | | isbn_ebook | 978-3-030-03526-6 | | copyright | Springer Nature Switzerland AG 2018 |
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