| 書目名稱 | The Polymerase Chain Reaction | | 編輯 | Kary B. Mullis,Fran?ois Ferré,Richard A. Gibbs | | 視頻video | http://file.papertrans.cn/918/917307/917307.mp4 | | 圖書封面 |  | | 描述 | James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc- ture we had divined from a minimum of experimental data and on theoretical argu- ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King‘s College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule‘s key feature-the complementary pairing of the bases. "It has not escaped our notice," Francis wrote, "that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material." By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two cha | | 出版日期 | Book 1994 | | 關(guān)鍵詞 | biochemistry; molecular biology; biology; chemistry | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4612-0257-8 | | isbn_softcover | 978-0-8176-3750-7 | | isbn_ebook | 978-1-4612-0257-8 | | copyright | Birkh?user Boston 1994 |
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