| 書目名稱 | Telomeres and Telomerase in Aging, Disease, and Cancer | | 副標(biāo)題 | Molecular Mechanisms | | 編輯 | K. Lenhard Rudolph | | 視頻video | http://file.papertrans.cn/903/902900/902900.mp4 | | 概述 | Provides an in depth review of our current knowledge on the role of telomeres and telomerase in ageing, disease and cancer.Special focus is on adult stem cells.Describes future directions in research | | 圖書封面 |  | | 描述 | Twenty-five years after the disclosure of the telomeric DNA sequence and 22 years after the discovery of telomerase, it has become clear that telomeres and telomerase influence disease of human ageing including cancer. This book summarizes our current knowledge on the role of telomeres and telomerase in ageing, regeneration, and cancer with a special focus on ageing stem cells. Moreover, the book reviews current ef forts to target telomeres and telomerase for anticancer treatment or reg- erative therapies. 1. 1 Ageing The molecular analysis of ageing is an emerging research field that will have great impact on patients care, lifestyle, and on disease prevention in the human population worldwide. Major molecular mechanisms that influence the ageing process include (1) the accumulation of molecular damage affecting DNA and p- teins, (2) alterations in gene expression, including alterations in checkpoint responses, metabolic pathways, and developmental pathways, and (3) the decline in adult stem cell function. All these mechanisms lead to a decrease in organ main- nance and function, thus representing a major factor limiting the quality of life d- ing ageing. Moreover, the accumulatio | | 出版日期 | Book 2008 | | 關(guān)鍵詞 | Ageing; DNA; Telomere; aging; apoptosis; cancer; cell; cell lines; development; influence; molecular mechanism | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-73709-4 | | isbn_softcover | 978-3-642-09288-6 | | isbn_ebook | 978-3-540-73709-4 | | copyright | Springer-Verlag Berlin Heidelberg 2008 |
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