| 書目名稱 | Targeted Genome Editing Using Site-Specific Nucleases | | 副標(biāo)題 | ZFNs, TALENs, and th | | 編輯 | Takashi Yamamoto | | 視頻video | http://file.papertrans.cn/901/900609/900609.mp4 | | 概述 | Equips readers with a basic understanding of genome editing methods, allowing for further developments in the field.Provides detailed methods for generation of engineered nucleases.Describes applicati | | 圖書封面 |  | | 描述 | .This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A | | 出版日期 | Book 2015 | | 關(guān)鍵詞 | CRISPR/Cas9; Gene disruption; Gene knockout; Genome editing; Knock-in; TALEN; Targeted insertion; ZFN; iPS; T | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-55227-7 | | isbn_softcover | 978-4-431-56235-1 | | isbn_ebook | 978-4-431-55227-7 | | copyright | Springer Japan 2015 |
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