| 書目名稱 | Systems Analysis of Chromatin-Related Protein Complexes in Cancer | | 編輯 | Andrew Emili,Jack Greenblatt,Shoshana Wodak | | 視頻video | http://file.papertrans.cn/885/884821/884821.mp4 | | 概述 | Defining high-quality protein-protein interaction networks and the physical and functional characterization of the protein machines underlying the human chromatin interactome.Identification of RNA mol | | 圖書封面 |  | | 描述 | .???????????????????????.Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie ?environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research..Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. .To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines ?- namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery..What makes this book distinctive is its emphasis on the systematic exploration of chromatin p | | 出版日期 | Book 2014 | | 關(guān)鍵詞 | DNA methylation; chromatin structure; histone chaperones; histone demethylases; proteomics; somatic mutat | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-7931-4 | | isbn_softcover | 978-1-4939-0089-3 | | isbn_ebook | 978-1-4614-7931-4 | | copyright | Springer Science+Business Media New York 2014 |
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