Titlebook: Synthesis and Biological Evaluation of Pyrrole–Imidazole Polyamide Probes for Visualization of Telom; Yusuke Kawamoto Book 2019 Springer N

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,Introduction: Sequence-Specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications,ic manner without causing denaturation of the DNA. These compounds can be used to control gene expression and to stain specific sequences in cells. Here, we review the history, structural variations, and functional investigations of Py–Im polyamides.

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,Targeting 24?bp Within Telomere Repeat Sequences with Tandem Tetramer Pyrrole–Imidazole Polyamide Plation of gene expression, and visualization of specific genomic regions. Increasing the number of base pairs targeted by synthetic molecules strengthens their sequence specificity. Our group has been working on the development of pyrrole–imidazole polyamides that bind to the minor groove of DNA in

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Springer Nature Singapore Pte Ltd. 2019

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Synthesis and Biological Evaluation of Pyrrole–Imidazole Polyamide Probes for Visualization of Telom978-981-13-6912-4Series ISSN 2190-5053 Series E-ISSN 2190-5061

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Yusuke KawamotoNominated by Kyoto University as an outstanding Ph.D. thesis.Includes a review chapter summarizing the history of and recent studies on Py–Im.Describes in detail the synthesis of Py–Im polyamides usin

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