Titlebook: Supramolecular Structure and Function 8; Greta Pifat-Mrzljak Conference proceedings 2004 Springer Science+Business Media New York 2004 Bio

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The Relationship Between Protein Sequence, Structure and Function,, several routes are being followed to address the problem, each having advantages and pitfalls. The present challenge is to use our understanding of protein evolution to develop accurate methods for large-scale automatic assignment of function. At present, the level of accuracy with which we can pr

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Differences in Binding of Stereoisomers to Protein Active Sites,s constructed from chiral building blocks and spatially arranged in handed conformations. Accordingly, enantiomers will be recognized as different species at the binding sites of such receptors. Some rare cases have been reported on the crystallographically determined binding mode of both enantiomer

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Time Resolved Protein Fluorescence. Application to Multi-Tryptophan Proteins,fferent rotameric states that interconvert only slowly if at all. The dead end elimination method has allowed us to explore these rotamers and in many cases links could be made with lifetimes on the basis of differences in accessibility. Experimental indications for the existence of different rotame

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A 2D-Infrared Study of Human Lipoproteins,t based in the changes induced by an external perturbation, temperature in our study, which increases the sensibility of the infrared analysis. Thus, from the results presented above is clear that in VLDL and LDL, opposite to HDL, the amide I spectrum is dominated by the special characteristics of a

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An Introduction to Biological Solid State NMR, With giant leaps continuing to be made in both hardware and computational aspects of the technique as well as continual development of increasingly complex pulse sequences, solid state NMR will continue to provide a unique insight into the structure and behaviour of important biological molecules a

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The Relationship Between Protein Sequence, Structure and Function,dinated effort of many research groups hold the promise that experimental biologists will soon be able to add reliable functional assignment tools to the suite of the many computational methods that are already part of their laboratory toolbox.

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