Titlebook: Sudden Cardiac Death in the Young and Athletes; Text Atlas of Pathol Gaetano Thiene,Domenico Corrado,Cristina Basso Book 2016 Springer-Verl

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Molecular Pathology and Genetic Testing,Molecular autopsy in case of cardiac SD aims to investigate DNA/RNA into two different settings: (a) myocarditis, for the detection of infective agents, mainly DNA and RNA cardiotropic viruses and (b) structural and nonstructural genetically determined heart disease, for the search of gene mutations [1, 2].

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Gaetano Thiene,Domenico Corrado,Cristina BassoPresents a wealth of high-resolution color images documenting anatomic pathology.Explains the role of molecular investigations in establishing the etiology of cardiac defects associated with sudden de

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Ion Channel Disease,d ion channel diseases, now listed among nonstructural cardiomyopathies [6, 7]. Circumstances of death and the availability of the 12-lead ECG recorded during life are of utmost importance to address the investigation [5] (Fig. 9.1).

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ng the etiology of cardiac defects associated with sudden de.This text atlas focuses on the pathology and molecular genetics of sudden cardiac death in the young and in athletes, presenting the state of the art in the field as the basis for development and implementation of more effective prevention

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The Northeast Italy, Veneto Region Experience,the incidence was 0.9/100,000/year and among athletes was 2.3/100,000/year [1]. Thus the occurrence of SD was 2.5-fold in athletes vs. nonathletes (. <0.0001). In the time interval (1980–2013), a total of 650 SCD were studied at postmortem (201 F, 31 %): it was mechanical in 7 % and arrhythmic in 93 % [1] (Fig. 12.1).

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Definition, Epidemiology, and Pathophysiologic Mechanisms,1 h from the onset of symptoms, in healthy even vigorous people or in people whose preexisting morbid conditions did not foresee such an abrupt outcome [1–18]. This temporal definition refers to witnessed SD, whereas it should be extended to 24 h for unwitnessed SD victims known to be alive and heal

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