Titlebook: Structural Approaches to Sequence Evolution; Molecules, Networks, Ugo Bastolla,Markus Porto,Michele Vendruscolo Book 2007 Springer-Verlag B

噱頭

1618-7210 l requirements constrain the evolution of biological entities at all levels, from macromolecules to their networks, right up to populations of biological organisms. Classical models of molecular evolution, however, are focused at the level of the symbols - the biological sequence - rather than that

PANEL

The Structurally Constrained Neutral Model of Protein Evolutionose evolutionary tree coincides with the tree of the species containing them. The practical importance of the study of molecular evolution became therefore evident as a way to reconstruct natural histories.

陰險(xiǎn)

Molecular Phylogenetics: Mathematical Framework and Unsolved Problemsal details for each of them, illustrate analytically and numerically the potential biases inherent in these methods, and outline computational challenges and unresolved problems. This is followed by a brief discussion of the Bayesian approach that has been recently used in molecular phylogenetics.

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Gene3D and Understanding Proteome Evolution of sequence similarity. Using remote homologue detection methods, we have been able to assign structures – based on the CATH [2] and Pfam [3] databases – to a majority of these sequences. This allows a high resolution view of the functions and evolution of specific protein families, as well as the evolution of a species‘ gene content.

Fibrillation

Modeling Conformational Flexibility and Evolution of Structure: RNA as an Example molecular basis of structure formation, optimization, adaptation, and evolution in simple systems. Two classes of landscapes are considered (1) conformational landscapes mapping RNA conformations into free energies of formation and (2) sequence-structure mappings assigning minimum free energy struc

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The Evolution of the Globins: We Thought We Understood It These gave us our first glimpse of the structural changes that take place during protein evolution. Many other structures of proteins in the globin family have continued to reveal interesting and important details of the coordinated divergence during evolution of amino acid sequences and protein st

恃強(qiáng)凌弱

宣稱

A Twenty-First Century View of Evolution: Genome System Architecture, Repetitive DNA, and Natural Ge genomes have changed in the course of biological evolution. The last 50 years of molecular genetics have produced an abundance of new discoveries and data that make it useful to revisit some basic concepts and assumptions in our thinking about genomes and evolution. Chief among these observations a

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