Titlebook: Stromal Immunology; Benjamin M.J Owens,Matthew A. Lakins Book 2018 Springer International Publishing AG, part of Springer Nature 2018 Cell

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Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures,tokines has been ascribed as responsible for TLS formation at different anatomical sites. Here we review the structural elements as well as the signals responsible for TLS aggregation, aiming to provide an overview to this complex immunological phenomenon.

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Stromal Cells in the Tumor Microenvironment,e cells and responses; CAFs both inhibit immune cell access to the tumor microenvironment and inhibit their functions within the tumor. Finally, we describe the potential modulation of CAF function as an adjunct to bolster the effectiveness of cancer immunotherapies.

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Leukocyte-Stromal Interactions Within Lymph Nodes,ed subsets such as integrin alpha-7+ pericytes. We focus on biomedically relevant interactions with T cells, B cells and dendritic cells, describing pro-survival mechanisms of support for these cells, promotion of their migration and tolerance-inducing mechanisms that help keep the body free of autoimmune-mediated damage.

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Stromal Cell Responses in Infection,rasitic helminths. Gaps in knowledge are identified, the challenges in studying stromal cell biology in the context of infection are highlighted, and the potential for stromal cell-targeted therapeutics is briefly discussed.

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Stromal Cell Responses in Infection,ction and as regulators of anti-infective immunity is in its infancy and still limited to a few well-worked examples. In this review, the role of stromal cells at each sequential stage of infection is discussed, with examples drawn from across the spectrum of infectious agents, from prions to the pa

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Fibroblasts and Osteoblasts in Inflammation and Bone Damage,f inflammation. Fibroblasts are key components of the stroma normally involved in maintenance of extracellular matrix and tissue function; however, the term ‘fibroblast’ is used to describe a heterogeneous population of cells that vary in phenotype both between and within anatomical sites. Fibroblas

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Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures,gregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules (HEVs) and local activation of resident stromal cells. B-cell proliferation and affinity maturation towards locally displayed autoantigens have been demonstrated at those sites, known as tertiary lympho

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