Titlebook: Stem Cell Therapy for Diabetes; Shimon Efrat Book 2010 Humana Press 2010 Diabetes.Immunity.Pancreas.Regulation.Tissue Engineering.cell bio

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Cell Cycle Regulation in Human Pancreatic Beta Cellsnot exist in any quantitatively meaningful way. This view has changed dramatically in the past decade, with abundant data demonstrating that fetal, neonatal, and adult rodent β cells replicate at physiologically important rates. These new data have resulted in a plethora of new reports exploring the

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What Does It Take to Make a Beta Cell? 1 diabetes has a near complete loss of β cells owing to autoimmune destruction, type 2 diabetes is associated with a 40–60% reduction in β-cell mass. Insulin resistance, brought on by our Western lifestyle coupled with genetic factors, is clearly of major importance, but diabetes only develops when

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Generation of Beta Cells from Acinar Cells the pancreas, a switch from an acinar to a β-cell phenotype in vitro can be induced by soluble agents, such as growth factors and cytokines. We found that the combination of epidermal growth factor and leukemia inhibitory factor stimulated the transdifferentiation of rat acinar cells into β cells i

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