Titlebook: Stem Cell Aging: Mechanisms, Consequences, Rejuvenation; Hartmut Geiger,Heinrich Jasper,Maria Carolina Flor Book 2015 Springer-Verlag Wien

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Aging of Murine Hematopoietic Stem Cellsese processes is crucial for tissue maintenance during the lifetime of the organism. However, with age the functionality of HSCs declines, resulting in development of anemias, deficiencies of immune response, and increased risk of hematopoietic malignancies. Aged HSCs are characterized by preferenti

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Aging of the Hematopoietic Stem Cell Nichesoperties of self-renewal and multilineage differentiation are controlled by direct interaction with a specific microenvironment – the so-called stem cell ‘niche’. Conceptual advances in our understanding of the composition of the HSC compartment suggest that changes in the BM HSC microenvironment ma

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Hematopoietic Stem Cell Aging and Leukemogenesis dramatic changes in hematopoiesis. As all mature hematopoietic cells are derived from multipotent hematopoietic stem cells (HSCs), age-dependent changes in these cells likely contribute to both alterations in hematopoiesis and increases in blood cancers. In this chapter, we will review the various

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