| 書目名稱 | Statistics in Clinical Vaccine Trials | | 編輯 | Jozef Nauta | | 視頻video | http://file.papertrans.cn/877/876746/876746.mp4 | | 概述 | First comprehensive text on the current state of the statistical methodology for clinical vaccines trials.Many worked-out real-life examples.SAS codes for the more complex examples provided.Includes s | | 圖書封面 |  | | 描述 | This monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The book‘s scope is practical rather than theoretical. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the statistical methodology. Many real-life examples and SAS codes are presented, making application of the methods straightforward. Topics discussed include maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of equivalence and non-inferiority immunogenicity trial data, analysis of data from vaccine field efficacy trials (including data from studies with recurrent infection data), fitting protection curves to data of challenge or field efficacy studies, and the analysis of vaccine safety data. | | 出版日期 | Book 20111st edition | | 關(guān)鍵詞 | Clinical Trials; Clinical Trials; Statistics; Statistics; Vaccines; Vaccines | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-14691-6 | | isbn_softcover | 978-3-642-44191-2 | | isbn_ebook | 978-3-642-14691-6 | | copyright | Springer-Verlag Berlin Heidelberg 2011 |
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